Centre for Genomic Regulation (CRG Barcelona, Spain)
Organization and Competences: The CRG is an emerging world-class interdisciplinary research institute focused around the study of the genome. It is located at the PRBB Research Park, one of the largest research clusters in southern Europe. The CRG is organized into 6 scientific programmes, including 'Bioinformatics and Genomics', which hosts the group of Dr. Gabaldón. The institute comprises state-of-the art core facilities, including, among others, DNA Ultra-sequencing (with 3 Illumina Solexas and a Roche 454 instrument), DNA Microarray, and Bioinformatics. The Gabaldon's lab is composed of 4 post-docs, 3 Ph.D. students, and 1 technician, whose backrgoud combine biology, computational science, and statistics. The main aim of the group is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve across species. This is achieved by the use of large-scale phylogenetics and other evolutionary analysis approaches that allow looking at the evolution of genomes from the perspective of all of their genes. In the past the group has applied these analyses to a variety of biological questions related the evolution and function of organelles, pathways, and organisms. We also are involved in the development of several bioinformatics tools to analyse evolution and function at a genome-scale.
Role: Participation in WP4
Staff members' profile:
Dr. Toni Gabaldón-group leader at the CRG, associate professor at the UPF.
Dr. Jaime Huerta-Cepas- post-doc. Genome-wide evolutionary analysis.
Dr. Marina Marcet-Houben- postdoc.
Genome wide analysis and computational biology. Another member of the team involved in
Dr. Salvador Capella-Gutíerrez
Network of experts/projects: The group has very extensive experience in genomic data analysis, including genome sequencing, comparative genomics, and the construction and analysis of large scale phylogenetic data. We have participated in several large genomic projects in the past including the sequencing of the pea aphid Acyrtosiphon pisum, the red algae Chondrus crispus, and the Melon crop Cucumis melo. In these projects we have not only been responsible on the comparative and
evolutionary analysis of the sequences obtained, but we have also significantly contributed to the phases of genome assembly, gene prediction and, genome annotation. Regarding this last aspect, we are able to use on a large-scale, phylogeny-based method for orthology and paralogy prediction that constitutes to date the most sophisticated and accurate genome-wide pipeline for genome annotation. Dr. Gabaldón has obtained competitive grants including an ERA-NET Pathogenomics, AICR, and several from the Ministry of Science.